(DE) -Ubiquitination in The TGF-β Pathway

Aberrations in the enzymes that modify ubiquitin moieties have been observed to cause a myriad of diseases, including cancer. Therefore a better understanding of these enzymes and their substrates will lead to the identification of prospective druggable targets. Here we discuss the role of ubiquitin modifying enzymes in the canonical TGF-β pathway highlighting the ubiquitin regulating enzymes, which may potentially be targeted by small molecule inhibitors.

Visit the following link for full text of the article: http://www.jscholaronline.org/full-text/JCRTO/102/(de)-ubiquitination-in-the-tgf-beta-pathway

A Putative Role of Organic Anion Transporting Polypeptides (OATPs) In Cell Survival of Hormone-Dependent Breast and Prostate Cancers

Transporter proteins classified into the solute carrier (SLC) superfamily are essential for import of nutrients for cell survival in organisms. In the last two decades, compelling evidence has accumulated that SLC transporters interact with clinically important anticancer agents and contribute to their pharmacokinetics, particularly the biopharmaceutical processes of absorption, elimination and distribution. Furthermore, many SLC transporters have been shown to be differentially upregulated in cancer cells, and this may represent an adaptive response to altered nutritional requirements. Thus, it is likely to utilize them as carrier for efficient drug delivery as well as pharmacological target to shut off the nutrients essential for cell growth of malignant tumors. This short review will introduce organic anion transporting polypeptides which recognize endo- and exogenous organic anionic compounds and recent findings about their upregulation in cancer cells. Besides, OATP-mediated transport of sulfate conjugates of steroid hormone may contribute to cell survival and adapted growth under hormonedepleted conditions. Better understandings of pathophysiological role of OATPs may provide key information to overcome hormone-refractory breast and prostate tumors.

Visit the following link for full text of the article: http://www.jscholaronline.org/full-text/JCRTO/101/a-putative-role-of-organic-anion-transporting-polypeptides-(oatps)-in-cell-survival-of-hormone-dependent-breast-and-prostate-cancers

Journal of Clinical and Anatomic Pathology from JScholar Publishers

Journal of Clinical and Anatomic Pathology from JScholar is an online Open Access Journal, which publishes articles on quarterly basis. It aims to publish the concurrent research trends in clinical and anatomical pathology. It focuses on research areas such as pathogenesis, pathological symptoms, prognosis and diagnosis. The journal is particularly dedicated to the publication of pathology research works and accepts suitable articles pertaining to the pathology and its allied divisions. The editor-in-chief and members of the Editorial Board will examine contributions from any qualified worker from any part of the world.

Journal of Clinical and Anatomic Pathology from JScholar Publishers

Journal of Dentistry & Oral Health

Journal of Dentistry & Oral Health from Jscholar is an online Open Access Journal which focuses on areas related to dental problems, prevention, diagnosis, and treatment of mouth and jaw deformities, pathoses, and injuries, and detecting other medical conditions from teeth / mouth health. Journal of Dentistry & Oral Health is a  bimonthly journal which publishes scientific articles related to dental field. The mission of the journal is to publish novel and high quality research papers. It aims to provide current research topics on disorders of the oral cavity and its diagnosis.

Journal of Dentistry & Oral Health from JScholar Open Access Journals

Journal of Cardiology and Vascular Medicine (JCVM):

Journal of Cardiology and Vascular Medicine is an international open access, scholarly peer-reviewed journal publishing high quality articles in all areas of cardiology and vascular related fields, especially current research, new concepts, novel methods, new therapeutic agents, and approaches for early detection and prevention of cardiac disorders and reporting new methods on basic and advanced clinical aspects of cardiology research.   

Journal of Cardiology and Vascular Medicine from JScholar Open Access Journals

Journal of Cancer Research and Therapeutic Oncology(JCRTO):

Journal of Cancer Research and Therapeutic Oncology(JCRTO) is an international open access, scholarly peer-reviewed journal publishing high quality articles in all areas of cancer related fields, especially current research, new concepts, novel methods, new therapeutic agents, and approaches for early detection and prevention of cancer and reporting new methods on basic and advanced clinical aspects of cancer research and therapy.

Journal of Cancer Research and Therapeutic Oncology(JCRTO) from JScholar Open Access Journals

JOURNAL OF HIV/AIDS AND INFECTIOUS DISEASES (JAID):

Journal of HIV/Aids & Infectious Diseases is an intentional online journal which dedicated to quarterly publishing high-quality papers that describe the most significant and cutting-edge research in all areas of aids and other sexually transmitted diseases such as HPV, Genital herpes, Chlamydia, Gonorrhea and their immunological interactions.

http://jscholaronline.org/journals/journal-of-hiv-aids-and-infectious-diseases/aim-and-scope.php

Scholarly publisher of peer reviewed articles

The manuscripts submitted to JScholar will be put into extensive reviewer critique, prior to accepting them for publication in respective journal. When an article is submitted to JScholar, the editors of the journal send it to other scholars in the same subject to get their opinion on the quality of the article.

http://www.jscholaronline.org/submit-manuscript.php